(170) Heart Transplant Survival and the Use of Donors with Intracranial Bleeding: Unos Registry Propensity Matched Analysis

PurposeThe transplantation of hearts from donors who suffered intracranial bleeding (ICB) has been associated with inferior long-term survival in both single-center analyses and, more recently, the UNOS registry. The purpose this study was to further explore relationship through propensity matching recipients receiving donor ICB and non-ICB a large national registry.MethodsWe performed retrospective cohort analysis Registry OPTN 2006-2018 for adult candidates wait-listed isolated heart transplantation. Recipients were stratified by donors. Propensity score estimate causal effects Kaplan-Meier used posttransplant. Cox proportional hazards modeling evaluated independent effect as COD.ResultsA total 25315 met inclusion criteria. Head trauma leading COD group, while cerebrovascular amongst group. (N=5529) older (median age, 42 vs. 27 years; P<0.001), less likely men (68.9% 75.7%; often had history smoking (20.1% versus 11.7%; hypertension (34.2% 9.5%; P<0.001). Prior there significant difference posttransplant (60.7% [59.5%,.61.9%] 56.8% [54.7%, 59.0%]; P<0.0001). However, when analyzing propensity-matched groups outcomes, no found between cohorts terms well rates rejection, yet younger age improved recipient survival.ConclusionIn largest transplants experienced ICB, we similar rejection transplant recipients. Future studies should address specific subpopulations within group concerns about survival. We COD. A In